AS the world deals with various existing and emerging infectious diseases, it’s crucial to distinguish between them to understand their transmission, symptoms, and preventive measures. Two diseases that recently have made headlines and declared public health emergencies are mpox (previously known as monkeypox) and Coronavirus Disease 2019 (Covid-19). While both causative agents are viruses and can lead to significant health concerns, they are fundamentally different in their origins, symptoms, transmission modes, and treatment.